Clinical Outcomes of Submucosal Invasive Gastric Cancer After Endoscopic Submucosal Dissection: A Single-Center Study

Submucosal invasive gastric cancer (SMGC) presents a clinical challenge, particularly when detected in its early stages. Endoscopic Submucosal Dissection (ESD) has emerged as a promising treatment modality, offering a less invasive approach than traditional surgery while enabling en bloc resection and precise histological evaluation.

This blog explores the clinical outcomes of SMGC following ESD, as reported in a single-center retrospective study — and how such findings could influence global practices in gastrointestinal oncology.

What Is Submucosal Invasive Gastric Cancer?

SMGC is a form of early-stage gastric cancer that extends into the submucosal layer. Its invasive nature requires timely intervention to prevent lymphovascular spread. Traditionally, gastrectomy with lymph node dissection has been the treatment standard — but ESD is now proving to be a viable, organ-preserving alternative.

Why ESD Is a Game-Changer in SMGC

ESD enables complete removal of gastric lesions with minimal disruption to surrounding tissue. This technique provides:

·         High en bloc and R0 resection rates

·         Accurate histopathological assessment

·         Lower complication and recurrence rates when performed by skilled endoscopists

In this single-center study, patients who underwent ESD for SMGC demonstrated excellent local control and comparable long-term outcomes to those treated surgically.

Study Highlights: Clinical Outcomes at a Glance

The retrospective analysis found:

·         En bloc resection rate: 95%

·         R0 resection rate: 89%

·         Local recurrence rate: <2%

·         Overall survival: Comparable to surgery in patients without high-risk lymphovascular invasion

These results underscore the growing relevance of ESD in treating select cases of SMGC, especially in centers with high procedural expertise.

Submit Your Abstract on Gastric Oncology or ESD Research

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